Investigating how Epstein-Barr virus affects cells in the nasopharynx
Epstein-Barr virus molecular pathogenesis in the nasopharynx and the role of LMP1 in lytic infection
This study is looking at how the Epstein-Barr virus (EBV) behaves in the throat area and how it might lead to a type of cancer called nasopharyngeal carcinoma, using special 3-D models to better understand the virus's effects on cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11009915 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the Epstein-Barr virus (EBV) in the nasopharynx, particularly how it can cause lytic infection and its implications for nasopharyngeal carcinoma (NPC). By utilizing advanced 3-D cell culture models, the study aims to explore the molecular mechanisms of EBV pathogenesis, specifically the function of the latent membrane protein 1 (LMP1) in triggering lytic infection. The research will analyze how EBV interacts with different cell types in the nasopharyngeal epithelium, which cannot be effectively studied in traditional 2-D cultures. This innovative approach may provide insights into the early stages of EBV-related cancers and the immune response to the virus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with nasopharyngeal carcinoma or those at high risk for EBV-related diseases.
Not a fit: Patients who do not have EBV infections or nasopharyngeal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential new treatments for EBV-related nasopharyngeal cancers.
How similar studies have performed: Previous research has shown promising results using 3-D cell culture models to study viral infections, indicating that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Shair, Kathy — University of Pittsburgh at Pittsburgh
- Study coordinator: Shair, Kathy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.