Investigating how Epstein-Barr virus affects B cells in the tonsils
Epstein-Barr Virus Driven Tonsillar Versus Peripheral B-cell One-Carbon Metabolic Network Remodeling
This study is looking at how the Epstein-Barr virus affects immune cells in the tonsils, which could help us understand and find new treatments for diseases linked to the virus, like Burkitt lymphoma and multiple sclerosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11084469 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between the Epstein-Barr virus (EBV) and B cells in the tonsils, which are crucial for the virus's lifecycle. By examining how EBV alters the metabolic processes of these immune cells, the study aims to uncover the mechanisms that lead to various diseases associated with EBV, such as Burkitt lymphoma and multiple sclerosis. The research will involve analyzing the behavior of B cells in the tonsil microenvironment to identify potential therapeutic targets. Patients may benefit from insights that could lead to new treatments for EBV-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of Epstein-Barr virus infection or related lymphoproliferative disorders.
Not a fit: Patients who do not have a history of Epstein-Barr virus infection or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases linked to Epstein-Barr virus, potentially reducing the burden of conditions like Burkitt lymphoma.
How similar studies have performed: Previous research has shown promising results in understanding EBV's role in B cell malignancies, indicating that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Gewurz, Benjamin Elison — Brigham and Women's Hospital
- Study coordinator: Gewurz, Benjamin Elison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.