Investigating how epithelial stem cells affect the development and maintenance of Meibomian glands
Official title: Epithelial stem cells in Meibomian gland development and homeostasis
Funded at University of Virginia · NIH-11055848 · Data updated 2026-11-12
This study is looking at how special cells in your eyelids help keep your eyes lubricated and how problems with these cells can cause dry eye disease, with the hope of finding new ways to help people who suffer from this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 30, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2023 |
| Award (this year) | $275,293 |
| NIH project number | 7R01EY033344-03 |
| Project ID | NIH-11055848 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals suffering from dry eye disease, particularly those with Meibomian gland dysfunction.
✕Less likely to help
Patients with dry eye disease not related to Meibomian gland dysfunction may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of epithelial stem cells in the development and maintenance of Meibomian glands, which are crucial for eye lubrication. The study aims to explore how dysfunction in these glands can lead to dry eye disease, a condition affecting millions of adults. By examining the mechanisms of stem cell differentiation and gland function, the research seeks to identify potential therapeutic targets for improving eye health. Patients may benefit from insights that could lead to new treatments for dry eye disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for dry eye disease, enhancing the quality of life for affected patients.
How similar studies have gone: Other research has shown promising results in understanding gland dysfunction and stem cell roles in similar conditions, indicating potential for success in this area.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Le, Lu — University of Virginia
- Study coordinator: Le, Lu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.