Investigating how epigenomic regulators affect DNA replication in pancreatic cancer
Targeting Epigenomic Regulators at the Replication Fork in PDAC
This study is looking at how certain factors in pancreatic cancer cells help them survive when their DNA is under stress, with the hope of finding better treatments for patients battling this tough cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11054584 on NIH RePORTER |
What this research studies
This research focuses on pancreatic adenocarcinoma (PDAC), a challenging cancer to treat, by exploring new therapeutic targets and strategies. The study aims to understand how epigenomic regulators, particularly G9a, influence the tolerance of cancer cells to replication stress during DNA replication. By examining the interactions between these regulators and critical DNA damage response pathways, the research seeks to uncover mechanisms that could lead to improved treatment options for patients. The approach involves detailed analysis of cellular processes during different stages of the cell cycle, particularly during DNA replication.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic adenocarcinoma who may benefit from new therapeutic approaches.
Not a fit: Patients with other types of cancer or those who do not have pancreatic adenocarcinoma may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatment strategies that enhance the effectiveness of therapies for pancreatic cancer.
How similar studies have performed: While the specific approach of targeting epigenomic regulators during DNA replication in PDAC is relatively novel, similar strategies in other cancers have shown promising results.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Lomberk, Gwen — Medical College of Wisconsin
- Study coordinator: Lomberk, Gwen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.