Investigating how epigenetic inheritance affects cell behavior and diseases
Study epigenetic inheritance during development, homeostasis and regeneration
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11126655
This study is looking at how tiny changes in our genes can affect how cells grow and heal, which could help us understand diseases like cancer and brain disorders, and it's especially focused on fruit fly stem cells to learn more about these processes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11126655 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how epigenetic mechanisms influence gene expression and cell behavior during development and regeneration. By studying the inheritance of histones in Drosophila stem cells, the researchers aim to uncover the processes that lead to different cell fates and how failures in these processes can contribute to diseases like cancer and neurodegenerative disorders. The approach involves exploring the mechanisms of histone incorporation and developing methods to identify genetic loci with epigenetic signatures, which could provide insights into cellular functions and disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by diseases related to epigenetic changes, such as certain cancers, neurodegenerative diseases, or infertility.
Not a fit: Patients with conditions unrelated to epigenetic mechanisms or those who are not affected by the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to epigenetic dysregulation, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding epigenetic mechanisms, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, XIN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: CHEN, XIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers