Investigating how epigenetic changes affect gene regulation during development.
Core B - Epigenomics Core
This study is looking at how changes in our genes, called epigenetic modifications, affect the development of the nervous system, and it aims to help people understand how these changes might be linked to developmental disorders.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11017618 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of epigenetic modifications, such as DNA methylation and histone modifications, in regulating genes during the development of the neural tube in humans and model organisms like mice and frogs. By using advanced multi-omic sequencing techniques, the project aims to generate comprehensive epigenomic data that can identify gene regulatory elements and variants that may influence various phenotypes. Patients may benefit from insights gained about how these epigenetic factors contribute to developmental disorders or diseases. The research involves collaboration among multiple projects to validate findings and enhance the understanding of gene regulation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with developmental disorders or those interested in genetic and epigenetic factors affecting health.
Not a fit: Patients with conditions unrelated to developmental processes or epigenetic influences may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into developmental disorders and potential therapeutic targets for related conditions.
How similar studies have performed: Previous research in epigenomics has shown promising results in understanding gene regulation and its implications for various diseases, indicating that this approach has potential for success.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Ecker, Joseph R — University of California, San Diego
- Study coordinator: Ecker, Joseph R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.