Investigating how epigenetic aging affects racial disparities in early-onset prostate cancer
Official title: Epigenetic aging as a driver of racial disparities in early onset prostate cancer
Funded at Roswell Park Cancer Institute Corp · NIH-10983413 · Data updated 2026-11-12
This study is looking at how biological aging might be linked to the higher rates of early-onset prostate cancer in African American men, and it hopes to find ways to help reduce this risk by comparing their aging markers to those of European American men.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $726,928 |
| NIH project number | 1R01CA298785-01 |
| Project ID | NIH-10983413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American men diagnosed with early-onset prostate cancer.
✕Less likely to help
Patients who do not have prostate cancer or are not of African descent may not benefit from this research.
What this research studies
This research focuses on understanding the link between epigenetic aging and the higher rates of early-onset prostate cancer in African American men. It examines how ancestry and race may influence biological aging markers, specifically ribosomal DNA methylation, which could explain the increased risk of prostate cancer in this population. By comparing the epigenetic age of African American prostate cancer patients to that of European American patients, the study aims to identify factors contributing to these disparities. The findings could lead to targeted interventions to reduce the risk of early-onset prostate cancer in African American men.
Why it matters
Potential benefit: If successful, this research could lead to improved screening and prevention strategies for early-onset prostate cancer in African American men.
How similar studies have gone: Previous research has indicated that epigenetic markers can provide insights into cancer risk, suggesting potential for success in this novel approach.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: Woloszynska-Read, Anna — Roswell Park Cancer Institute Corp
- Study coordinator: Woloszynska-Read, Anna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.