Investigating how Eph receptors interact and signal in the body
Eph Receptor Heterointeractions in Signaling
['FUNDING_R01'] · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · NIH-11088915
This study is looking at how certain proteins in our cells, called Eph receptors, work together and affect things like cell behavior, which could help us find new ways to treat diseases like cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11088915 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the interactions between Eph receptors, a type of protein that plays a crucial role in cell signaling. By using advanced biophysical techniques, the study aims to explore how these receptors form complexes and how these interactions influence various biological processes, including their potential roles in diseases like cancer. The research will involve detailed analysis of the EphA2 receptor, which is known to have complex effects on cell behavior. Patients may benefit from insights gained into how these signaling pathways can be targeted for therapeutic purposes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with conditions related to EphA2 signaling, such as certain types of cancer.
Not a fit: Patients with conditions unrelated to Eph receptor signaling may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases associated with EphA2 signaling, particularly cancer.
How similar studies have performed: While the specific interactions of Eph receptors have not been extensively studied, similar approaches in receptor signaling research have shown promising results in understanding complex biological systems.
Where this research is happening
LA JOLLA, UNITED STATES
- SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PASQUALE, ELENA B — SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Study coordinator: PASQUALE, ELENA B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.