Investigating how Eph receptors interact and signal in cells
Eph Receptor Heterointeractions in Signaling
This study is exploring how certain proteins called Eph receptors work together and communicate, especially focusing on EphA2, which is connected to cancer, to help us understand their roles in health and disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11237820 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between Eph receptors, a type of protein involved in cell signaling. By studying how these receptors form complexes and communicate with each other, the research aims to uncover their roles in various biological processes and diseases. The team will employ advanced biophysical techniques to analyze these interactions, particularly looking at EphA2, which is linked to cancer. This work could provide insights into how these receptors contribute to cell behavior and disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to Eph receptor signaling, particularly those with cancer.
Not a fit: Patients with conditions unrelated to Eph receptor signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting Eph receptors in diseases like cancer.
How similar studies have performed: While the specific interactions of Eph receptors have not been extensively studied, similar approaches in receptor signaling have shown promise in other research.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Pasquale, Elena B — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Pasquale, Elena B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.