Investigating how eosinophils affect SIV infection
Role of eosinophils in SIV infection
This study is looking at how a type of immune cell called eosinophils behaves during SIV infection, which is similar to HIV, to see if they help fight the virus or cause problems, and it’s aimed at helping people with chronic infections understand their health better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10669240 on NIH RePORTER |
What this research studies
This research explores the role of eosinophils, a type of immune cell, in the context of SIV infection, which is similar to HIV. It aims to understand how these cells contribute to antiviral responses and whether they can help clear the virus or cause inflammation and tissue damage. The study will involve examining eosinophils in the intestines of infected individuals to see how they behave during infection. By analyzing these immune responses, researchers hope to uncover new insights into managing chronic infections and associated health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with chronic HIV or SIV infections who may be experiencing related health complications.
Not a fit: Patients who do not have chronic HIV or SIV infections are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing chronic infections and reducing associated health risks for patients.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in similar contexts, suggesting potential for success in this exploratory approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Manickam, Cordelia — Duke University
- Study coordinator: Manickam, Cordelia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.