Investigating how eosinophil proteins affect heart muscle growth
Official title: Role of eosinophil cationic proteins in cardiac hypertrophy
Funded at Brigham and Women's Hospital · NIH-10890866 · Data updated 2026-11-12
This study is looking at how certain white blood cells called eosinophils might help protect your heart and keep it healthy, especially when it comes to thickening of the heart muscle, which can happen due to inflammation and other heart risks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 19, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $699,381 |
| NIH project number | 5R01HL166538-02 |
| Project ID | NIH-10890866 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cardiovascular diseases, particularly those experiencing cardiac hypertrophy or related conditions.
✕Less likely to help
Patients without cardiovascular issues or those who do not have elevated eosinophil levels may not benefit from this research.
What this research studies
This research explores the role of eosinophils, a type of white blood cell, and their cationic proteins in the development of cardiac hypertrophy, a condition where the heart muscle thickens. By studying animal models and human samples, the research aims to understand how eosinophils contribute to heart health and disease, particularly in the context of inflammation and cardiovascular risk factors. The researchers will examine the mechanisms by which eosinophils may protect against heart muscle damage and promote healing.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that harness eosinophil proteins to prevent or reverse heart muscle thickening and improve outcomes for patients with cardiovascular diseases.
How similar studies have gone: While the role of eosinophils in cardiovascular diseases is still being explored, previous studies have shown promising results regarding their involvement in heart health, indicating potential for success in this area.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Libby, Peter — Brigham and Women's Hospital
- Study coordinator: Libby, Peter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.