Investigating how eosinophil proteins affect heart muscle growth
Role of eosinophil cationic proteins in cardiac hypertrophy
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10890866
This study is looking at how certain white blood cells called eosinophils might help protect your heart and keep it healthy, especially when it comes to thickening of the heart muscle, which can happen due to inflammation and other heart risks.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10890866 on ClinicalTrials.gov |
What this research studies
This research explores the role of eosinophils, a type of white blood cell, and their cationic proteins in the development of cardiac hypertrophy, a condition where the heart muscle thickens. By studying animal models and human samples, the research aims to understand how eosinophils contribute to heart health and disease, particularly in the context of inflammation and cardiovascular risk factors. The researchers will examine the mechanisms by which eosinophils may protect against heart muscle damage and promote healing.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cardiovascular diseases, particularly those experiencing cardiac hypertrophy or related conditions.
Not a fit: Patients without cardiovascular issues or those who do not have elevated eosinophil levels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that harness eosinophil proteins to prevent or reverse heart muscle thickening and improve outcomes for patients with cardiovascular diseases.
How similar studies have performed: While the role of eosinophils in cardiovascular diseases is still being explored, previous studies have shown promising results regarding their involvement in heart health, indicating potential for success in this area.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIBBY, PETER — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: LIBBY, PETER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.