Investigating how environmental factors affect lung cancer risk through genetic mechanisms
Functional Genomics of LINE-1 Retrotransposition
['FUNDING_R01'] · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · NIH-11012386
This study is looking at how certain pollutants in the environment, like benzo(a)pyrene, can harm the DNA in lung cells and possibly increase the risk of lung cancer, helping patients understand how their genes and surroundings might affect their lung health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR (nih funded) |
| Locations | 1 site (COLLEGE STATION, UNITED STATES) |
| Trial ID | NIH-11012386 on ClinicalTrials.gov |
What this research studies
This research explores the interactions between genes and environmental pollutants, particularly focusing on how substances like benzo(a)pyrene can damage DNA in lung cells. By utilizing advanced sequencing technologies, the study aims to understand how these genetic changes may lead to increased susceptibility to lung cancer. The research also examines the role of LINE-1 retrotransposons, which can disrupt normal gene function and contribute to cancer development. Patients may gain insights into how their genetic makeup interacts with environmental factors to influence their lung health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of exposure to environmental pollutants or those with a family history of lung cancer.
Not a fit: Patients who do not have any risk factors for lung cancer or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of lung cancer risk factors and potentially inform personalized prevention strategies.
How similar studies have performed: Previous research has shown promising results in understanding gene-environment interactions in cancer, making this approach both relevant and potentially impactful.
Where this research is happening
COLLEGE STATION, UNITED STATES
- TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR — COLLEGE STATION, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAMOS, KENNETH S. — TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
- Study coordinator: RAMOS, KENNETH S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.