Investigating how environmental factors affect colitis through a specific receptor
Role of the environmental sensor, AhR on colitis
This study is looking at how a specific protein in your body, called the aryl hydrocarbon receptor, affects inflammation in the gut, especially for people with inflammatory bowel disease (IBD), and it explores whether a compound found in certain foods can help improve gut health and ease symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10900874 on NIH RePORTER |
What this research studies
This research focuses on the role of the aryl hydrocarbon receptor (AhR) in regulating inflammation in the gastrointestinal tract, particularly in conditions like inflammatory bowel disease (IBD). The study aims to understand how certain dietary compounds, specifically indole-3-carbinol (I3C), can influence the immune response and potentially alleviate symptoms of colitis. By examining the interactions between AhR ligands and gut microbiota, the research seeks to uncover mechanisms that could lead to new dietary interventions for managing IBD. Patients may benefit from insights into how their diet can impact their condition and overall gut health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including conditions like ulcerative colitis and Crohn's disease.
Not a fit: Patients without inflammatory bowel disease or those who do not have a history of gastrointestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that help reduce inflammation and improve symptoms in patients with inflammatory bowel disease.
How similar studies have performed: Previous research has shown promising results with dietary interventions targeting the AhR pathway, suggesting potential for success in this area.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Nagarkatti, Prakash S — University of South Carolina at Columbia
- Study coordinator: Nagarkatti, Prakash S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.