Investigating how environmental chemicals affect autism through metabolomics
Environmental chemical mixtures and metabolomics in autism spectrum disorder
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10732253
This study is looking at how chemicals in the environment might affect the development of autism in children by checking their teeth for clues about when they were exposed to these substances, both before and after they were born.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10732253 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between environmental chemical exposures and autism spectrum disorder (ASD) by analyzing metabolites in teeth. Using innovative techniques, the study aims to identify when during development—before and after birth—children are most vulnerable to these exposures. By examining tooth matrix biomarkers, researchers can trace back the timing and types of toxic exposures that may contribute to ASD. This approach combines targeted and untargeted metabolomics to provide a comprehensive understanding of how these factors interact with child health.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with autism spectrum disorder, particularly those under the age of one.
Not a fit: Patients who are older than one year or do not have a diagnosis of autism spectrum disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for autism by identifying harmful environmental exposures.
How similar studies have performed: While the approach of using metabolomics in this context is relatively novel, previous studies have shown promising results in linking environmental exposures to various health outcomes.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PETRICK, LAUREN — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: PETRICK, LAUREN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: disease causation, autism spectrum disorder