Investigating how enhancer RNAs affect gene regulation in Alzheimer's disease
Official title: Enhancer RNAs in brain gene regulation and Alzheimer's disease
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11042820 · Data updated 2026-11-12
This study is looking at how certain tiny molecules in the brain might help control genes linked to Alzheimer's disease, with the hope of finding new ways to prevent or treat the memory loss that comes with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $721,789 |
| NIH project number | 5R01AG082132-03 |
| Project ID | NIH-11042820 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at high risk due to genetic factors.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of enhancer RNAs in the regulation of genes related to Alzheimer's disease (AD). By examining how these noncoding RNAs function in the brain, the study aims to uncover the molecular mechanisms that contribute to the development and progression of AD. The approach involves analyzing genetic variants and epigenetic changes in brain tissues from individuals with AD, which may reveal new therapeutic targets for treatment. Patients may benefit from insights that could lead to innovative strategies for preventing cognitive decline associated with Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets and strategies to alleviate symptoms or slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in understanding the role of genetic and epigenetic factors in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Li, Wenbo — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Li, Wenbo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.