Investigating how energy metabolism in the brain may lead to Alzheimer's disease.
Sporadic Alzheimer's Disease: A Bioenergetic Etiology?
This study is looking at how problems with brain energy use might play a role in developing late-onset Alzheimer's disease, and it's for anyone interested in understanding how age, sex, and genetics can affect brain health and early signs of Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project ID | NIH-10552701 on NIH RePORTER |
What this research studies
This research explores whether dysfunction in brain energy metabolism contributes to the development of late-onset sporadic Alzheimer's disease (sAD). It examines how factors like age, sex, and genetic status (specifically the apolipoprotein E gene) interact to affect brain energy and amyloid metabolism. The study uses innovative mouse models that mimic human genetic conditions related to sAD and analyzes blood samples from both these models and human participants at various stages of cognitive health. By understanding these mechanisms, the research aims to identify early changes that could signal the onset of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's, those carrying specific genetic markers, and individuals experiencing mild cognitive impairment.
Not a fit: Patients with advanced Alzheimer's disease or those without any genetic risk factors for the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early detection and prevention of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of bioenergetics in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Lawrence, United States
- University of Kansas Lawrence — Lawrence, United States (Active)
Researchers
- Principal investigator: Zhao, Liqin — University of Kansas Lawrence
- Study coordinator: Zhao, Liqin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.