Investigating how energy metabolism affects Dravet Syndrome
Gluconeogenic control of Dravet Syndrome
This study is looking at how problems with sugar processing in the body might affect seizures in kids with Dravet Syndrome, and it hopes to find new ways to help manage these symptoms using a zebrafish model.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10842345 on NIH RePORTER |
What this research studies
This research explores the metabolic disruptions in Dravet Syndrome, a severe childhood epilepsy caused by genetic mutations. By using a zebrafish model, the study aims to understand how glucose regulation impacts seizures and related health issues. The researchers will test whether inhibiting specific enzymes involved in glucose metabolism can replicate or alleviate the symptoms observed in this condition. This approach could lead to new therapeutic strategies for managing Dravet Syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Dravet Syndrome who experience frequent seizures and related health challenges.
Not a fit: Patients with other forms of epilepsy or those without a diagnosis of Dravet Syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve seizure control and overall health for patients with Dravet Syndrome.
How similar studies have performed: While the specific metabolic approach in Dravet Syndrome is novel, similar research in other genetic epilepsies has shown promising results.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Patel, Manisha N — University of Colorado Denver
- Study coordinator: Patel, Manisha N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.