Investigating how energy failure and synaptic dysfunction contribute to Parkinson's disease
Synaptic Dysfunction and Energy Failure in Parkinson's Disease
This study is looking at how problems with brain cells that produce dopamine happen early on in Parkinson's disease, even before any symptoms show up, using special mice that have similar genetic traits to humans with the condition. Researchers want to learn more about how energy issues in these cells affect their health and communication, which could help us understand how Parkinson's develops.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-11076272 on NIH RePORTER |
What this research studies
This research focuses on understanding the early events in Parkinson's disease, particularly how synaptic dysfunction in dopamine neurons occurs before symptoms appear. Using a transgenic mouse model that mimics human genetic mutations associated with Parkinson's, the study examines the role of mitochondrial dysfunction and its impact on neuronal health and communication. By analyzing mitochondrial dynamics and energy production in these models, researchers aim to uncover critical mechanisms that lead to the disease's progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a familial history of Parkinson's disease or those who exhibit early signs of the disease.
Not a fit: Patients with advanced Parkinson's disease or those without genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target early synaptic dysfunction and energy failure in Parkinson's disease.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Zhang, Hui — University of Georgia
- Study coordinator: Zhang, Hui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.