Investigating how Endothelin-1 affects brain development and healing
Endotelin-1 role in development and regeneration
This study is looking at how a substance called Endothelin-1 affects the growth and healing of brain white matter in newborns who have experienced brain injuries, with the hope of finding new ways to help babies who might develop conditions like cerebral palsy or learning delays.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11090084 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Endothelin-1 in the development and regeneration of white matter in the brain, particularly in neonates who suffer from diffuse white matter injury (DWMI). The study aims to uncover the cellular mechanisms that lead to myelination issues and associated disabilities such as cerebral palsy and cognitive delays. By examining the behavior of oligodendrocyte progenitor cells (OPCs) and their maturation processes, the research seeks to identify the molecular signals that regulate these cells during both normal brain development and after injury. This could lead to new insights into potential therapeutic strategies for affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are neonates who have experienced diffuse white matter injury or are at risk for myelination disorders.
Not a fit: Patients who are older children or adults, or those without a history of neonatal brain injury, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for neonates suffering from brain injuries, potentially reducing the incidence of disabilities like cerebral palsy and cognitive delays.
How similar studies have performed: While the specific role of Endothelin-1 in this context may be novel, previous research has shown success in understanding signaling pathways related to brain injury and myelination.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Vittorio Gallo, Vittorio Gallo Vittorio Gallo — Seattle Children's Hospital
- Study coordinator: Vittorio Gallo, Vittorio Gallo Vittorio Gallo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.