Investigating how Endothelin-1 affects atrial fibrillation development and progression
Official title: Role of Endothelin-1 signaling in the development and progression of atrial fibrillation
Funded at Northwestern University at Chicago · NIH-10914162 · Data updated 2026-11-12
This study is looking at how a molecule called Endothelin-1 affects heart rhythm problems like atrial fibrillation, with the goal of finding new ways to help people who have this condition feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $163,080 |
| NIH project number | 5K08HL169904-02 |
| Project ID | NIH-10914162 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atrial fibrillation, particularly older adults or those with conditions like heart failure, hypertension, or diabetes.
✕Less likely to help
Patients who do not have atrial fibrillation or related cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of Endothelin-1, a molecule involved in blood vessel function, in the development and worsening of atrial fibrillation (AF), a common heart rhythm disorder. Using large animal models, the study aims to explore how endothelial dysfunction contributes to AF and its transition from a temporary to a more persistent form. By examining the timing and location of these changes, researchers hope to uncover new therapeutic targets that could lead to more effective treatments for patients suffering from AF.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for atrial fibrillation, potentially reducing the risk of stroke and other complications for patients.
How similar studies have gone: Previous studies have indicated a link between endothelial dysfunction and atrial fibrillation, but this research aims to establish a causal relationship, making it a novel approach.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Pfenniger, Anna — Northwestern University at Chicago
- Study coordinator: Pfenniger, Anna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.