Investigating how endothelial cells can influence immune responses after organ transplants
Official title: Targeting complement-induced IL-15 trans-presentation by human endothelial cells
Funded at Yale University · NIH-10992626 · Data updated 2026-11-12
This study is looking at how certain proteins in the body can help protect blood vessel cells during organ transplants, with the goal of reducing the chances of the body rejecting the new organ while still keeping the immune system strong against infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $203,094 |
| NIH project number | 5R21AI180187-02 |
| Project ID | NIH-10992626 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals undergoing organ transplantation who may be at risk for transplant rejection.
✕Less likely to help
Patients who are not undergoing organ transplantation or those with contraindications for gene editing procedures may not benefit from this research.
What this research studies
This research focuses on understanding how complement proteins affect endothelial cells during and after organ transplants. It examines the role of these cells in activating immune responses that can lead to transplant rejection. By using gene editing techniques on endothelial cells before transplantation, the researchers aim to reduce the risk of rejection while still allowing the immune system to fight infections. The study involves complex interactions between immune cells and endothelial cells, which are crucial for transplant success.
Why it matters
Potential benefit: If successful, this research could lead to improved transplant outcomes and longer-lasting organ grafts for patients.
How similar studies have gone: Previous research has shown promise in using gene editing to enhance transplant success, indicating that this approach may lead to significant advancements.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Pober, Jordan S — Yale University
- Study coordinator: Pober, Jordan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.