Investigating how ENDOG affects mitochondrial DNA release and inflammation in Parkinson's disease
ENDOG mediates mtDNA release and inflammation
This study is looking at how a specific protein called ENDOG affects the release of mitochondrial DNA in Parkinson's disease and how this release might cause inflammation that makes symptoms worse, with the hope of finding new ways to help manage the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | U.s. National Inst/neuro/ds/stroke NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10712192 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of ENDOG, an endonuclease, in the release of mitochondrial DNA (mtDNA) and its connection to inflammation in Parkinson's disease (PD). The study aims to uncover the mechanisms that prevent excessive mtDNA release, which can trigger inflammatory responses that worsen neurodegeneration. By examining how mtDNA interacts with the immune system, the research seeks to identify potential therapeutic targets that could mitigate the inflammatory processes associated with PD. Patients may benefit from insights that could lead to new treatment strategies aimed at slowing disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with Parkinson's disease.
Not a fit: Patients with other neurodegenerative disorders or those without a diagnosis of Parkinson's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that reduce inflammation and slow the progression of Parkinson's disease.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dynamics and inflammation in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Bethesda, United States
- U.s. National Inst/neuro/ds/stroke — Bethesda, United States (Active)
Researchers
- Principal investigator: Cupo, Ryan R — U.s. National Inst/neuro/ds/stroke
- Study coordinator: Cupo, Ryan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.