Investigating how ENDOG affects mitochondrial DNA release and inflammation in Parkinson's disease
Official title: ENDOG mediates mtDNA release and inflammation
Funded at U.s. National Inst/neuro/ds/stroke · NIH-10712192 · Data updated 2026-11-12
This study is looking at how a specific protein called ENDOG affects the release of mitochondrial DNA in Parkinson's disease and how this release might cause inflammation that makes symptoms worse, with the hope of finding new ways to help manage the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | U.s. National Inst/neuro/ds/stroke NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| NIH project number | 1FI2GM150431-01 |
| Project ID | NIH-10712192 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with Parkinson's disease.
✕Less likely to help
Patients with other neurodegenerative disorders or those without a diagnosis of Parkinson's disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of ENDOG, an endonuclease, in the release of mitochondrial DNA (mtDNA) and its connection to inflammation in Parkinson's disease (PD). The study aims to uncover the mechanisms that prevent excessive mtDNA release, which can trigger inflammatory responses that worsen neurodegeneration. By examining how mtDNA interacts with the immune system, the research seeks to identify potential therapeutic targets that could mitigate the inflammatory processes associated with PD. Patients may benefit from insights that could lead to new treatment strategies aimed at slowing disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that reduce inflammation and slow the progression of Parkinson's disease.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial dynamics and inflammation in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
U.s. National Inst/neuro/ds/stroke
Bethesda, United States Active
Researchers
- Principal investigator: Cupo, Ryan R — U.s. National Inst/neuro/ds/stroke
- Study coordinator: Cupo, Ryan R
Related research
Other NIH-funded projects on the same topics.
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This study looks at how brain cells manage a protein called tubulin, which is important for their health and function, to help us understand more about brain conditions and improve treatments for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.