Investigating how endocannabinoids control seizures in epilepsy
Activity-dependent endocannabinoid control in epilepsy
This study is looking at how certain natural substances in the body, called endocannabinoids, might help control seizures in people with temporal lobe epilepsy, and it hopes to find new ways to treat those who struggle with frequent seizures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11064806 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of endocannabinoids in regulating seizures in patients with temporal lobe epilepsy (TLE). By utilizing advanced tools to monitor and manipulate specific brain cells in living mice, the researchers aim to uncover how cannabinoid signaling is altered in chronic epilepsy. The study will explore the potential of non-invasive interventions to target these signaling pathways, which could lead to new treatment options for patients suffering from uncontrolled seizures.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with temporal lobe epilepsy and experience uncontrolled seizures.
Not a fit: Patients with epilepsy types other than temporal lobe epilepsy or those who do not respond to cannabinoid therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly reduce seizure frequency and improve the quality of life for patients with temporal lobe epilepsy.
How similar studies have performed: Previous research has shown promising results in using cannabinoid therapies for various neurological disorders, suggesting potential success for this novel approach in epilepsy.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Soltesz, Ivan — Stanford University
- Study coordinator: Soltesz, Ivan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.