Investigating how emergency myelopoiesis contributes to the development of acute myeloid leukemia.
Project 1: Role of emergency myelopoiesis as a driver of clonal evolution in AML
This study is looking at how certain changes in the body, like inflammation and genetic mutations, can affect blood cells and possibly lead to acute myeloid leukemia (AML), helping us understand how this disease develops over time.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10935669 on NIH RePORTER |
What this research studies
This research aims to understand the role of emergency myelopoiesis (EM) in the development of acute myeloid leukemia (AML) by examining how inflammatory changes in the environment and genetic mutations interact to drive clonal evolution in the disease. The study will explore the mechanisms by which hematopoietic stem cells adapt to these changes and how this adaptation may lead to leukemia. By analyzing the epigenetic regulation of blood precursor cells, the research seeks to uncover new insights into the progression of AML and its relationship with aging and inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acute myeloid leukemia or those with pre-leukemic conditions.
Not a fit: Patients with other types of leukemia or those without any hematological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating acute myeloid leukemia by targeting the mechanisms of clonal evolution and emergency myelopoiesis.
How similar studies have performed: While the specific approach of linking emergency myelopoiesis to clonal evolution in AML is relatively novel, there have been successful studies exploring the role of inflammation and epigenetics in leukemia.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Passegue, Emmanuelle — Columbia University Health Sciences
- Study coordinator: Passegue, Emmanuelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.