Investigating how elevated pressure in the brain affects certain neurons after injury
Effects of ICP elevation on NeuN Negative Membrane Disrupted Neurons
This study is looking at how high pressure inside the skull affects certain brain cells after a head injury, with the hope of finding better treatments for headaches and other long-term problems that can happen after a traumatic brain injury.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10877220 on NIH RePORTER |
What this research studies
This research focuses on understanding the effects of elevated intracranial pressure (ICP) on neurons that are disrupted after a traumatic brain injury (TBI). The study aims to identify a specific group of neurons that do not express a common neuronal marker (NeuN) and are affected by membrane disruption. By using advanced techniques, researchers will explore the cellular and molecular mechanisms behind these changes, which could lead to better insights into post-traumatic headaches and other long-term impairments associated with TBI. The findings may help in developing targeted therapies for patients suffering from these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are suffering from post-traumatic headaches or related symptoms.
Not a fit: Patients who have not experienced a traumatic brain injury or do not have post-traumatic headaches may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients experiencing long-term effects from traumatic brain injuries, particularly those with post-traumatic headaches.
How similar studies have performed: Other research has shown promising results in understanding neuronal responses to traumatic brain injuries, but this specific investigation into NeuN-negative neurons is relatively novel.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Hernandez, Martina Laura — Duke University
- Study coordinator: Hernandez, Martina Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.