Investigating how eicosanoids affect heart disease in people with HIV
Official title: The study of Eicosanoids as Novel Inflammatory Mediators of CVD in Men and Women with HIV
Funded at University of Miami School of Medicine · NIH-11061057 · Data updated 2026-11-12
This study is looking at how certain compounds in the body might affect heart health in people living with HIV, especially focusing on how inflammation can increase the risk of heart disease, and it aims to find ways to help both men and women stay healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | April 7, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $682,957 |
| NIH project number | 5R01HL167658-03 |
| Project ID | NIH-11061057 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are experiencing or at risk for cardiovascular disease.
✕Less likely to help
Patients who do not have HIV or those without cardiovascular disease may not benefit from this research.
What this research studies
This research explores the role of eicosanoids, which are bioactive compounds derived from fatty acids, in the development of cardiovascular disease (CVD) among individuals living with HIV. It aims to understand how chronic inflammation and immune activation contribute to CVD risk, particularly focusing on differences between men and women. By identifying specific inflammatory biomarkers, the study seeks to uncover the mechanisms behind increased heart disease risk in HIV patients and develop targeted therapies to mitigate this risk.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce cardiovascular disease risk in people living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in cardiovascular disease, but this specific approach focusing on eicosanoids in HIV patients is relatively novel.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Martinez, Claudia — University of Miami School of Medicine
- Study coordinator: Martinez, Claudia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.