Investigating how edelfosine affects gut bacteria after seizures
Official title: Determining the Impact of Edelfosine on Restoring the Gut Microbiota after and Epileptic Insult
Funded at University of Puerto Rico Med Sciences · NIH-11019163 · Data updated 2026-11-12
This study is looking at how the drug edelfosine might help improve gut health in people who have had seizures by restoring the balance of good bacteria in their stomachs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico Med Sciences NIH-funded |
| Lab location | 1 site (San Juan, United States) |
| Project start | May 15, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $316,179 |
| NIH project number | 1P20GM156713-01 |
| Project ID | NIH-11019163 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with epilepsy who are experiencing disruptions in their gut microbiota.
✕Less likely to help
Patients who do not have epilepsy or those who are not affected by gut microbiota imbalances may not benefit from this research.
What this research studies
This research explores the effects of edelfosine, a drug, on the gut microbiota in patients who have experienced seizures. It aims to understand how this drug can help restore the balance of gut bacteria that may be disrupted after an epileptic event. By analyzing fecal samples from both healthy and seizure-affected animals, the study will assess changes in gut microbiota and metabolites over time. The goal is to determine if edelfosine can create a healthier gut environment, potentially leading to better seizure management.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for epilepsy by restoring gut health and reducing seizure frequency.
How similar studies have gone: Previous research has shown promising results in modulating gut microbiota to improve epilepsy outcomes, suggesting that this approach may be effective.
Where this research is happening
-
University of Puerto Rico Med Sciences
San Juan, United States Active
Researchers
- Principal investigator: Ferrer-Acosta, Yancy — University of Puerto Rico Med Sciences
- Study coordinator: Ferrer-Acosta, Yancy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.