Investigating how Ebola virus protein interacts with host proteins
Official title: Functional significance and mechanisms of Ebola Virus VP24-host protein interactions
Funded at Icahn School of Medicine at Mount Sinai · NIH-10996292 · Data updated 2026-11-12
This study is looking at how a protein from the Ebola virus interacts with proteins in our bodies, which could help us understand how the virus makes us sick and lead to new treatments for Ebola.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $76,756 |
| NIH project number | 1F32AI186388-01 |
| Project ID | NIH-10996292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of Ebola virus exposure or those who have been diagnosed with Ebola virus infection.
✕Less likely to help
Patients who are not at risk of Ebola virus exposure or those with other unrelated viral infections may not benefit from this research.
What this research studies
This research focuses on understanding the interactions between the Ebola virus protein VP24 and various host proteins. By using advanced techniques like affinity purification-mass spectrometry, the study aims to identify how VP24 interacts with host proteins both with and without the involvement of importin-alpha, a key nuclear transport protein. This could reveal new insights into the mechanisms by which the Ebola virus suppresses immune responses and contributes to its pathogenicity. Patients may benefit from this research as it could lead to the development of new therapeutic strategies against Ebola virus infections.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response against Ebola virus infections.
How similar studies have gone: Previous research has shown success in understanding viral-host protein interactions, indicating that this approach has potential for yielding valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Vogel, Olivia Ashley — Icahn School of Medicine at Mount Sinai
- Study coordinator: Vogel, Olivia Ashley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.