Investigating how early Retinoic Acid signaling affects heart valve development
Official title: Effects of early Retinoic Acid signaling on valve development
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11031300 · Data updated 2026-11-12
This study is looking at how a form of Vitamin A affects the early development of heart valves in zebrafish, which could help us understand heart valve problems in people and lead to better ways to prevent or treat these issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $41,915 |
| NIH project number | 5F31HL172346-02 |
| Project ID | NIH-11031300 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include infants and children with congenital heart defects, particularly those with valve-related issues.
✕Less likely to help
Patients with acquired heart valve diseases unrelated to congenital defects may not benefit from this research.
What this research studies
This research focuses on understanding the role of Retinoic Acid (RA), a derivative of Vitamin A, in the early development of heart valves. By studying zebrafish embryos, the researchers aim to uncover how RA signaling influences the formation and maintenance of cardiac valves, which are crucial for proper heart function. The findings could provide insights into congenital valve defects and their progression to more serious heart conditions later in life. This research may lead to new therapeutic strategies to prevent or treat valve diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment options for congenital valve defects and related heart diseases.
How similar studies have gone: Previous research has shown promising results in understanding heart development through similar signaling pathways, indicating potential for success in this area.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Fernandes, Andrew Theodore David — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Fernandes, Andrew Theodore David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.