Investigating how early life stress affects heart health in adults
Official title: Multi-Omics Core C
Funded at University of Alabama at Birmingham · NIH-11010885 · Data updated 2026-11-12
This study is looking at how stress in early life might affect your heart health later on, and it wants to see how this stress changes your genes and gut bacteria, so if you join in by sharing some samples, you can help us find ways to improve heart health for everyone.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $287,514 |
| NIH project number | 5P01HL158500-03 |
| Project ID | NIH-11010885 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are adults aged 21 and older who have experienced significant stress during their early life.
✕Less likely to help
Patients who have not experienced early life stress or those under 21 years old may not benefit from this research.
What this research studies
This research explores the connection between early life stress and the risk of developing cardiovascular disease (CVD) later in life. It focuses on understanding how stress can change gene expression and gut microbiome composition, potentially leading to health issues. By analyzing various biological samples, the study aims to identify specific changes in the body that could be targeted for intervention. Patients may contribute to this research by providing samples that help uncover these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular disease in individuals who experienced early life stress.
How similar studies have gone: Previous research has shown promising results in understanding the links between early life stress and health outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Hyndman, Kelly — University of Alabama at Birmingham
- Study coordinator: Hyndman, Kelly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.