Investigating how early exposure to Lactobacillus affects childhood respiratory health.
The effect of early-life nasal colonization with Lactobacillus on the development of the local immune response and the later onset of recurrent wheeze, childhood asthma, and allergic rhinitis
['FUNDING_OTHER'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10688072
This study is looking at how introducing a friendly bacteria called Lactobacillus to the noses of healthy babies, especially those born by cesarean section, might help prevent breathing problems like asthma and allergies as they grow up.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10688072 on ClinicalTrials.gov |
What this research studies
This research explores the role of early-life nasal colonization with Lactobacillus in shaping the immune response and its potential impact on preventing respiratory issues like asthma and allergic rhinitis in children. The study will involve healthy infants, particularly focusing on those born via cesarean section, to see if introducing Lactobacillus can alter their nasal microbiome positively. Researchers will assess the relationship between Lactobacillus colonization and the development of respiratory conditions, while also planning a randomized controlled trial to test vaginal seeding as an intervention. This approach aims to fill critical gaps in understanding how early microbiome exposure can influence long-term health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are healthy infants, especially those born by cesarean section.
Not a fit: Patients who are older than 11 years or those with existing respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing asthma and allergic conditions in children.
How similar studies have performed: Previous studies have indicated potential benefits of early microbiome interventions, but this specific approach is relatively novel and has not been extensively tested in humans.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROSAS-SALAZAR, CHRISTIAN — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: ROSAS-SALAZAR, CHRISTIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.