Investigating how early exposure to flame retardants and a western diet affects liver disease later in life
Official title: Late onset of metabolic liver disease from early life flame retardant exposure and adulthood western diet
Funded at University of Washington · NIH-10996387 · Data updated 2026-11-12
This study is looking at how being exposed to certain chemicals called flame retardants early in life might affect liver health later on, especially for people who eat a typical western diet, to help understand what causes fatty liver disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 6, 2024 |
| Project end | August 5, 2026 |
| Funding year | 2024 |
| Award (this year) | $45,574 |
| NIH project number | 1F31DK139707-01A1 |
| Project ID | NIH-10996387 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been exposed to flame retardants in early life and are experiencing symptoms related to metabolic liver disease.
✕Less likely to help
Patients who have not been exposed to flame retardants or do not exhibit symptoms of metabolic liver disease may not benefit from this research.
What this research studies
This research explores the connection between early life exposure to flame retardants and the development of metabolic-associated fatty liver disease (MAFLD) later in life, particularly in individuals who consume a western diet. It examines how these environmental stressors impact liver function and metabolism through various biological pathways, including the gut-liver axis. By studying the effects of flame retardants found in breast milk and their potential to disrupt metabolic processes, the research aims to identify critical factors that contribute to the onset of MAFLD.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for metabolic liver diseases linked to environmental exposures.
How similar studies have gone: Previous studies have indicated a link between environmental toxins and metabolic disorders, suggesting that this research builds on established findings rather than exploring a completely novel area.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Lim, Jongpyo Joe — University of Washington
- Study coordinator: Lim, Jongpyo Joe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.