Investigating how early exposure to certain chemicals affects liver disease.
Official title: Early Life Exposure to Endocrine Disrupting Chemicals: Epigenomic and Transcriptomic Networks and RAGE in Liver Disease
Funded at Beckman Research Institute/city of Hope · NIH-11076188 · Data updated 2026-11-12
This study is looking at how certain chemicals found in everyday products might affect liver health in kids and teens, especially if they're exposed to them before birth or when they're young, to see if this could lead to liver issues later on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | April 17, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $767,661 |
| NIH project number | 5R01ES034793-02 |
| Project ID | NIH-11076188 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adolescents who have been exposed to bisphenols or phthalates, particularly those with signs of liver disease or obesity.
✕Less likely to help
Patients who have not been exposed to these chemicals or do not have any liver-related health issues may not benefit from this research.
What this research studies
This research focuses on the effects of chemicals like bisphenol S, bisphenol F, and diisononylphthalate on liver health, particularly in children and adolescents. It aims to understand how exposure to these chemicals during pregnancy and early life may lead to conditions such as non-alcoholic fatty liver disease (NAFLD). The study will explore the biological mechanisms involved, including changes in gene expression and immune responses, to determine how these chemicals impact liver function over time.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for liver disease in children and adolescents.
How similar studies have gone: Previous studies have shown that early exposure to other endocrine disruptors can lead to significant health issues, suggesting that this research could yield important insights.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Trevino, Lindsey Starr — Beckman Research Institute/city of Hope
- Study coordinator: Trevino, Lindsey Starr
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.