Investigating how early environmental exposures affect prostate cancer risk

Discriminatory Mechanisms in Early-Onset and Lethal Prostate Cancer

['FUNDING_R01'] · PUBLIC HEALTH INSTITUTE · NIH-10922680

This study is looking at how things in our environment when we're young might affect the chances of developing aggressive prostate cancer later on, and it’s for young men and their families who want to understand more about this risk.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorPUBLIC HEALTH INSTITUTE (nih funded)
Locations1 site (OAKLAND, UNITED STATES)
Trial IDNIH-10922680 on ClinicalTrials.gov

What this research studies

This research explores how environmental factors during early development and young adulthood may influence the risk of developing early-onset and lethal prostate cancer. By analyzing blood samples from young men and their parents, the study aims to identify metabolic changes linked to these exposures. The researchers will use advanced analytical techniques to connect these metabolic signatures with the likelihood of developing aggressive prostate cancer before age 60. This approach could lead to new prevention strategies that enhance protective factors and mitigate risks associated with prostate cancer.

Who could benefit from this research

Good fit: Ideal candidates for this research are young men, particularly those with a family history of prostate cancer or who belong to populations at higher risk.

Not a fit: Patients who are older than 60 or those without a history of prostate cancer in their family may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to effective prevention strategies for early-onset and lethal prostate cancer.

How similar studies have performed: Previous research has shown promising results in understanding the links between environmental exposures and cancer risk, making this approach both innovative and grounded in existing findings.

Where this research is happening

OAKLAND, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.