Investigating how E-cadherin loss affects prostate inflammation and urinary issues in older men
Role of E-Cadherin Down-Regulation in Prostatic Inflammation and Lower Urinary Tract Dysfunction
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11042230
This study is looking at how a protein called E-cadherin affects prostate health and urinary issues in older men with benign prostatic hyperplasia (BPH), using a special mouse model to find new ways to help improve their quality of life.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11042230 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of E-cadherin, a protein important for cell connections, in benign prostatic hyperplasia (BPH) and related urinary tract symptoms in older men. The study uses a special mouse model that mimics age-related changes in the prostate to explore how the loss of E-cadherin leads to inflammation and urinary dysfunction. By examining the mechanisms behind these changes, the research aims to uncover potential targets for new treatments that could improve the quality of life for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are older men experiencing symptoms of benign prostatic hyperplasia or lower urinary tract dysfunction.
Not a fit: Patients who are younger or do not have symptoms related to benign prostatic hyperplasia are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing BPH and its associated urinary symptoms, significantly improving patient quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the role of cell adhesion proteins in prostate health, suggesting that this approach could yield valuable insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, ZHOU — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: WANG, ZHOU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age dependent disease, age dependent disorder, age related human disease