Investigating how Dynorphin affects insulin secretion and glucose regulation
Official title: Dynorphin, a novel paracrine factor that regulates insulin secretion
Funded at University of Miami School of Medicine · NIH-11064892 · Data updated 2026-11-12
This study is looking at how a molecule called Dynorphin affects insulin release from pancreatic cells, which could help us find new ways to improve blood sugar control for people with type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | April 17, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $345,375 |
| NIH project number | 5R01DK132095-03 |
| Project ID | NIH-11064892 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type 2 diabetes or those at risk of developing insulin resistance.
✕Less likely to help
Patients with type 1 diabetes or those without any insulin regulation issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of Dynorphin, a signaling molecule, in regulating insulin secretion from pancreatic cells. By studying the interactions between different types of cells in the pancreas, the research aims to uncover how these signals contribute to maintaining healthy blood sugar levels. The approach involves both mouse and human pancreatic cells to assess how Dynorphin influences insulin release and glucose homeostasis, particularly in conditions like type 2 diabetes. The ultimate goal is to identify new targets for improving insulin secretion in patients with insulin resistance.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance insulin secretion and improve blood sugar control in patients with diabetes.
How similar studies have gone: Previous research has shown promising results in understanding paracrine signaling in pancreatic cells, indicating potential for success in this novel approach.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Blandino-Rosano, Manuel — University of Miami School of Medicine
- Study coordinator: Blandino-Rosano, Manuel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.