Investigating how dynein affects kidney function in diabetes
Targeting dynein-mediated trafficking in diabetic podocytopathy
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-11082424
This study is looking at how a protein called dynein affects kidney cells in people with diabetes, with the goal of finding new ways to prevent kidney damage and improve treatments for diabetic nephropathy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11082424 on ClinicalTrials.gov |
What this research studies
This research focuses on diabetic nephropathy, a common kidney disease affecting many individuals with diabetes. It aims to understand how dynein, a motor protein, contributes to the mismanagement of proteins in kidney cells called podocytes, which are crucial for filtering blood. By exploring the mechanisms behind this mismanagement, the research seeks to identify potential therapeutic targets that could prevent the progression of kidney damage rather than just slowing it down. Patients may benefit from new treatments that address the root causes of kidney issues related to diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with diabetes who are at risk of developing diabetic nephropathy.
Not a fit: Patients without diabetes or those who do not have any kidney-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that prevent kidney damage in diabetic patients.
How similar studies have performed: Previous research has shown promising results in targeting cellular mechanisms in diabetic nephropathy, suggesting that this approach could yield significant advancements.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, HUA — UNIVERSITY OF IOWA
- Study coordinator: SUN, HUA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.