Investigating how drug abuse affects lung damage in HIV patients
Drug abuse and HIV-associated pulmonary vascular injury
['FUNDING_R01'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-10748368
This study is looking at how cocaine and HIV affect lung health in people with HIV, especially how they can lead to serious lung problems, and it aims to find ways to spot and prevent these issues early on.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-10748368 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the impact of cocaine and HIV on lung health, particularly how they contribute to pulmonary vascular injury and conditions like pulmonary arterial hypertension (HIV-PAH) in HIV-infected individuals. The study aims to explore the mechanisms behind this injury, particularly the role of pulmonary arterial smooth muscle cells and long noncoding RNAs in promoting cell proliferation and vascular remodeling. By identifying these processes, the research seeks to develop strategies for early diagnosis and prevention of lung complications in patients at risk due to drug abuse.
Who could benefit from this research
Good fit: Ideal candidates for this research include HIV-infected individuals who also have a history of cocaine use.
Not a fit: Patients who are HIV-negative or do not have a history of drug abuse may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for lung complications in HIV-infected individuals who abuse drugs.
How similar studies have performed: Previous research has indicated a link between drug abuse and pulmonary complications in HIV patients, suggesting that this approach is built on established findings.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DHILLON, NAVNEET KAUR — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: DHILLON, NAVNEET KAUR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.