Investigating how dopamine transporters behave in Parkinson's Disease
Exploring Dopamine Transporter Recycling and Trafficking Defects in Parkinson's Disease
This study is looking at how problems with dopamine transporters might cause the loss of important brain cells in people with Parkinson's Disease, with the hope of finding new ways to help prevent serious symptoms before they start.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11068091 on NIH RePORTER |
What this research studies
This research focuses on understanding the early mechanisms that lead to dopamine neuron loss in Parkinson's Disease (PD). By examining the recycling and trafficking of dopamine transporters, the study aims to identify how these processes are disrupted in various genetic forms of PD. Using advanced imaging techniques and in vitro models, researchers will explore the relationship between dopamine transporter function and the onset of motor impairments. This could lead to insights that help develop therapies to intervene before significant neuron loss occurs.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with genetic forms of Parkinson's Disease or those experiencing early symptoms of the condition.
Not a fit: Patients with advanced Parkinson's Disease or those without genetic predispositions to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that prevent or slow the progression of Parkinson's Disease.
How similar studies have performed: Previous research has shown promising results in understanding dopamine transporter dynamics in related conditions, suggesting potential for success in this novel approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Harmon, Leah Elizabeth — Yale University
- Study coordinator: Harmon, Leah Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.