Investigating how DnaJB6 regulates tau levels in Alzheimer's disease
Official title: DnaJB6 as a novel regulator of tau
Funded at University of South Florida · NIH-10873707 · Data updated 2026-11-12
This study is looking at how a protein called DnaJB6 can help keep tau levels in check, which is important for people with Alzheimer's disease, and it aims to find new ways to treat this condition by testing it in cells and mice.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 14, 2023 |
| Project end | August 13, 2026 |
| Funding year | 2024 |
| Award (this year) | $39,373 |
| NIH project number | 5F31AG082505-02 |
| Project ID | NIH-10873707 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with non-neurodegenerative cognitive impairments or those without any form of dementia may not benefit from this research.
What this research studies
This research focuses on understanding the role of DnaJB6 in regulating tau protein levels, which are implicated in Alzheimer's disease. The study will explore how DnaJB6 can prevent tau accumulation through various mechanisms, using both cell models and animal studies. Researchers will assess the interactions between DnaJB6 and tau proteins and observe the behavioral and molecular changes in mice with altered DnaJB6 levels. This could lead to new therapeutic strategies for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively lower tau levels and slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in targeting tau proteins for Alzheimer's treatment, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Esquivel, Abigail — University of South Florida
- Study coordinator: Esquivel, Abigail
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.