Investigating how DNA vaccines affect immune memory in HIV-infected individuals
Epigenetic Histone Landscape Profiles in HIV
This study is looking at how DNA vaccines can help people with HIV build a strong and lasting immune response, by checking how their immune cells change after getting vaccinated.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10669779 on NIH RePORTER |
What this research studies
This research aims to understand how DNA vaccines can create lasting immune memory in people living with HIV. By examining the changes in the epigenetic and transcriptional landscape of immune cells after vaccination, the study will utilize advanced techniques to analyze how these vaccines influence the body's immune response. The approach includes a systems immunology framework, which has previously been successful in mapping immune responses to other vaccines. Participants will be monitored for changes in their immune cell behavior and gene expression over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are interested in participating in vaccine trials.
Not a fit: Patients who are not infected with HIV or those who are not eligible for vaccination may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies that enhance immune responses in HIV-infected patients.
How similar studies have performed: Previous research has shown success in mapping immune responses to other vaccines, indicating potential for this approach in HIV vaccination.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Utz, Paul Joseph — Stanford University
- Study coordinator: Utz, Paul Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.