Investigating how DNA replication initiation factors contribute to diseases like cancer
Structure-Function Analysis of DNA Replication Initiation Factors Implicated in Disease
This study is looking at how DNA copies itself, which is really important for keeping our genes healthy, and it aims to find out how this process works differently in yeast and human cells, especially in cancer, so that we can learn more about potential new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10929367 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms of DNA replication initiation, which is crucial for maintaining genome stability. By using advanced imaging techniques, the team aims to visualize and quantify how DNA replication begins and how this process differs between yeast and human cells. The study will explore the role of specific proteins that regulate this initiation, particularly in the context of cancer, where these proteins are often over-expressed or mutated. Patients may benefit from insights gained into how these processes contribute to cancer development and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders related to DNA replication or those diagnosed with specific types of cancer.
Not a fit: Patients with conditions unrelated to DNA replication or those not affected by genetic alterations in replication factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with DNA replication errors.
How similar studies have performed: Previous research has shown success in understanding DNA replication mechanisms, but this approach using single-molecule imaging is relatively novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Chistol, Gheorghe — Stanford University
- Study coordinator: Chistol, Gheorghe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.