Investigating how DNA-PKcs interacts with PIDD in DNA damage response
DNA-PKcs and PIDD interaction in DNA damage response
This study is looking at how two important proteins help cells fix DNA damage, especially from things like UV light, to find ways to make cells stronger against such damage, which could help in developing better cancer treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10693192 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of DNA-PKcs, a crucial protein involved in repairing DNA damage, and its interaction with another protein called PIDD. By studying how these proteins work together, especially in response to DNA damage caused by factors like UV radiation, the research aims to uncover mechanisms that could improve cellular resistance to such damage. The team has developed specific cell lines and mouse models to explore these interactions further, which may lead to new insights into cancer treatment and prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that involve DNA damage, particularly those who may benefit from enhanced DNA repair mechanisms.
Not a fit: Patients with conditions unrelated to DNA damage or those who do not have cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing DNA repair mechanisms in patients, potentially reducing the impact of cancer treatments and improving outcomes.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach could yield significant insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Davis, Anthony J — Ut Southwestern Medical Center
- Study coordinator: Davis, Anthony J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.