Investigating how DNA-PKcs affects DNA repair and cancer development
The role of DNA-PKcs in DNA repair, lymphocyte development, RNA metabolism and tumor suppression
This study is looking at a protein called DNA-PKcs that helps fix damaged DNA and is linked to cancers like lymphoma and leukemia, with the goal of finding better treatments for patients by understanding how this protein works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10853032 on NIH RePORTER |
What this research studies
This research focuses on DNA-dependent protein kinase (DNA-PKcs), which plays a crucial role in repairing DNA and is involved in the development of certain cancers like lymphoma and leukemia. The study employs genetic and cell biology techniques to explore how DNA-PKcs functions during the repair of DNA damage and its implications for cancer therapy. By understanding the mechanisms of DNA-PKcs, researchers aim to identify new therapeutic targets and improve treatment strategies for patients with these cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with lymphoma or leukemia who may benefit from novel therapeutic approaches targeting DNA repair mechanisms.
Not a fit: Patients with cancers unrelated to DNA-PKcs or those not diagnosed with lymphoma or leukemia may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by targeting DNA-PKcs in lymphoma and leukemia patients.
How similar studies have performed: Other research has shown promising results in targeting DNA repair mechanisms in cancer therapy, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Zha, Shan — Columbia University Health Sciences
- Study coordinator: Zha, Shan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.