Investigating how DNA methylation affects the progression of COPD
Official title: EpiGNOME: Epigenetic Graphical Networks Of Methylation Effectors for COPD Progression
Funded at University of Florida · NIH-11072382 · Data updated 2026-11-12
This study is looking at how changes in DNA might affect the progression of Chronic Obstructive Pulmonary Disease (COPD) to help find better treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $725,817 |
| NIH project number | 1R01HL178032-01 |
| Project ID | NIH-11072382 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Chronic Obstructive Pulmonary Disease, particularly those experiencing varying disease progression.
✕Less likely to help
Patients with COPD who are not actively experiencing disease progression or those with other unrelated respiratory conditions may not benefit from this research.
What this research studies
This research explores the role of DNA methylation in the progression of Chronic Obstructive Pulmonary Disease (COPD). By utilizing advanced computational methods, the study aims to analyze large-scale data to identify how changes in DNA methylation relate to different subtypes of COPD and their progression. Patients may benefit from insights gained about the molecular mechanisms driving their condition, which could lead to improved treatment strategies. The research will involve collecting and analyzing biological samples, such as blood, to understand these relationships better.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with COPD.
How similar studies have gone: Previous research has shown promise in using DNA methylation analysis to understand other diseases, suggesting potential for success in this novel approach for COPD.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Benos, Panagiotis V — University of Florida
- Study coordinator: Benos, Panagiotis V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.