Investigating how DNA methylation affects gene expression regulation
Editing CG and non-CG DNA methylation to identify genomic elements that regulate gene expression
This study is looking at how our genes affect brain cells and how we can use a special tool to change certain DNA patterns, which might help us find new ways to treat different diseases in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10880706 on NIH RePORTER |
What this research studies
This research aims to understand the relationship between genetic information and the characteristics of cells, particularly in the human brain. It utilizes advanced CRISPR technology to edit DNA methylation patterns, which are crucial for regulating gene expression. By mapping these regulatory elements across human chromosomes, the study seeks to uncover how non-coding DNA influences cell function and development. Patients may benefit from insights gained about gene regulation that could lead to new treatments for various diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or neurological conditions that may be influenced by gene expression.
Not a fit: Patients with conditions unrelated to gene regulation or those who do not have genetic predispositions may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating conditions related to gene expression and regulation.
How similar studies have performed: Other research using CRISPR technology for gene regulation has shown promising results, indicating that this approach has potential for significant advancements.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Goodarzi, Hani — University of California, San Francisco
- Study coordinator: Goodarzi, Hani
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.