Investigating how DNA loops regulate gene expression in individual cells
Model-based methods for single cell chromatin interactomic data
This study is looking at how specific parts of our DNA work together to control gene activity, which can help us understand diseases better and potentially lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10877899 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain DNA elements, known as cis-regulatory elements (CREs), interact with genes to influence their expression. By using advanced techniques that analyze chromatin at the single-cell level, the study aims to uncover how these interactions occur within complex tissues. This approach allows researchers to visualize and interpret the spatial organization of DNA, which is crucial for understanding the genetic basis of various diseases. Patients may benefit from insights gained about gene regulation and its implications for disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with complex genetic diseases or traits that may be influenced by chromatin interactions.
Not a fit: Patients with conditions unrelated to chromatin regulation or those not participating in the research may not receive direct benefits.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for understanding and treating complex diseases linked to gene regulation.
How similar studies have performed: Other research has shown promising results using similar single-cell technologies to study chromatin interactions, indicating potential for success in this area.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Hu, Ming — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Hu, Ming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.