Investigating how DNA interacts with molybdenum disulfide for better genetic testing.
Charge Transfer Study of DNA/MoS2 interface
['FUNDING_R15'] · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · NIH-10514726
This study is looking at how certain DNA sequences interact with special surfaces to help create a new way to detect genetic mutations without needing labels, which could lead to better tests for genetic disorders caused by repeated DNA sequences.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SOUTHERN ILLINOIS UNIVERSITY CARBONDALE (nih funded) |
| Locations | 1 site (CARBONDALE, UNITED STATES) |
| Trial ID | NIH-10514726 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the interaction between tandem DNA repeats and molybdenum disulfide (MoS2) surfaces. By exploring how these DNA sequences transfer electrical charges, the study aims to develop a new, label-free platform for detecting genetic mutations. The project employs advanced techniques like electrochemical analysis and surface probe microscopy to gather detailed data on these interactions. If successful, this could lead to improved diagnostic methods for genetic disorders caused by DNA repeat expansions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetically transferrable disorders caused by tandem DNA repeat expansions.
Not a fit: Patients with genetic disorders not related to DNA repeat expansions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a more accurate and efficient method for diagnosing genetic disorders linked to DNA mutations.
How similar studies have performed: While the approach of using MoS2 for DNA interaction studies is innovative, similar research has shown promise in enhancing genetic testing technologies.
Where this research is happening
CARBONDALE, UNITED STATES
- SOUTHERN ILLINOIS UNIVERSITY CARBONDALE — CARBONDALE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAMSI, MOHTASHIM H — SOUTHERN ILLINOIS UNIVERSITY CARBONDALE
- Study coordinator: SHAMSI, MOHTASHIM H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.