Investigating how DNA interacts with molybdenum disulfide for better genetic testing.
Official title: Charge Transfer Study of DNA/MoS2 interface
Funded at Southern Illinois University Carbondale · NIH-10514726 · Data updated 2026-11-12
This study is looking at how certain DNA sequences interact with special surfaces to help create a new way to detect genetic mutations without needing labels, which could lead to better tests for genetic disorders caused by repeated DNA sequences.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Illinois University Carbondale NIH-funded |
| Lab location | 1 site (Carbondale, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $429,508 |
| NIH project number | 1R15GM147885-01 |
| Project ID | NIH-10514726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetically transferrable disorders caused by tandem DNA repeat expansions.
✕Less likely to help
Patients with genetic disorders not related to DNA repeat expansions may not benefit from this research.
What this research studies
This research focuses on understanding the interaction between tandem DNA repeats and molybdenum disulfide (MoS2) surfaces. By exploring how these DNA sequences transfer electrical charges, the study aims to develop a new, label-free platform for detecting genetic mutations. The project employs advanced techniques like electrochemical analysis and surface probe microscopy to gather detailed data on these interactions. If successful, this could lead to improved diagnostic methods for genetic disorders caused by DNA repeat expansions.
Why it matters
Potential benefit: If successful, this research could provide a more accurate and efficient method for diagnosing genetic disorders linked to DNA mutations.
How similar studies have gone: While the approach of using MoS2 for DNA interaction studies is innovative, similar research has shown promise in enhancing genetic testing technologies.
Where this research is happening
-
Southern Illinois University Carbondale
Carbondale, United States Active
Researchers
- Principal investigator: Shamsi, Mohtashim H — Southern Illinois University Carbondale
- Study coordinator: Shamsi, Mohtashim H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.