Investigating how DNA interacts with a special material to improve genetic testing
Official title: Charge Transfer Study of DNA/MoS2 interface
Funded at Southern Illinois University Carbondale · NIH-10798439 · Data updated 2026-11-12
This study is exploring how DNA interacts with a special material called molybdenum disulfide to create a new, easier way to test for genetic disorders that could give more accurate results without complicated steps.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Illinois University Carbondale NIH-funded |
| Lab location | 1 site (Carbondale, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $99,660 |
| NIH project number | 3R15GM147885-01S1 |
| Project ID | NIH-10798439 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by genetically transferrable disorders linked to tandem DNA repeats.
✕Less likely to help
Patients with disorders not related to DNA mutations or those not affected by tandem DNA repeats may not benefit from this research.
What this research studies
This research focuses on understanding the electrical properties of DNA when it is in contact with molybdenum disulfide (MoS2), a material that could enhance genetic testing methods. By studying how DNA repeats transfer electrical charges, the researchers aim to develop a new, label-free sensing platform that could provide more accurate genetic testing for various disorders. The project involves both theoretical and experimental approaches, including advanced microscopy techniques to validate findings. This innovative method seeks to overcome the limitations of current genetic testing technologies, which often yield false results or require complex procedures.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and efficient genetic testing for disorders caused by DNA mutations.
How similar studies have gone: While the approach of using MoS2 for DNA sensing is innovative, similar research has shown promise in enhancing genetic testing accuracy.
Where this research is happening
-
Southern Illinois University Carbondale
Carbondale, United States Active
Researchers
- Principal investigator: Shamsi, Mohtashim H — Southern Illinois University Carbondale
- Study coordinator: Shamsi, Mohtashim H
Related research
Other NIH-funded projects on the same topics.
-
Rapid pathogen ID and antibiotic testing for bacteremia using immune capture, microfluidics, and AI
A fast, AI-assisted diagnostic system will identify bacteria in blood and determine which antibiotics are likely to work, helping doctors treat bacteremia sooner.
-
Electrografted-MoS2 Immunosensor for Biomarker Detection
A university-led project is developing a robust, covalently linked antibody–MoS2 biosensor to detect biomedical markers.
-
Super-Resolution Confocal Microscope for SIU researchers
A new high-resolution confocal microscope will be purchased for Southern Illinois University, enabling researchers from multiple fields to generate clearer 3D images and advance biomedical work.
-
How social choices shape when to stay with a friend vs. seek food in mice
A study in mice will look at how the brain decides whether to stay with a social partner or pursue food when both options are available.
-
High-speed cell sorting technology for cancer and infectious disease research
A fast, multi-marker cell sorter is being purchased to help SIUC researchers study cancer, immune responses, and infections, plus train students in this cutting-edge technique.
-
How early life stress affects aggression through brain circuitry
This study is looking at how tough experiences in childhood, like feeling alone or going through trauma, can affect the brain and lead to aggressive behavior in adults, with the hope of finding better ways to help people manage their anger.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.