Investigating how DNA influences RNA splicing in diseases like cancer
Exploring hidden determinants of splicing with genome-targeted proximity labeling
['FUNDING_OTHER'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-11014637
This study is looking at how changes in DNA and RNA can affect diseases like cancer, hoping to find new ways to understand and treat these conditions better for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11014637 on ClinicalTrials.gov |
What this research studies
This research explores the complex relationship between DNA and RNA splicing, particularly in the context of diseases such as cancer. By examining how the chromatin state affects splicing outcomes, the study aims to uncover the hidden factors that regulate this process. The researchers will employ innovative experimental techniques to identify these determinants, which could lead to a better understanding of how splicing becomes dysregulated in cancer. Patients may benefit from insights gained into the mechanisms of their disease and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with various types of cancer, particularly those exhibiting abnormal splicing patterns.
Not a fit: Patients with non-cancerous conditions or those without splicing abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with cancers characterized by abnormal RNA splicing.
How similar studies have performed: Previous research has shown promising results in understanding RNA splicing mechanisms, but this approach aims to uncover novel insights that have not yet been fully explored.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHOI, PETER S. — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: CHOI, PETER S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.